Retina vasculature morphogenesis in camera-type eye

Across TCGA cell cohorts, RNA activity of the Retina vasculature morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO2A, TENM3, and FBRSL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CORO2A grouped by Retina vasculature morphogenesis in camera-type eye-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CORO2A →	+2.566	+1.448	<.001	.002	3	4
URINARY_TRACT	TENM3 →	-3.573	-1.770	.003	.001	2	5
BONE	FBRSL1 →	+2.149	+1.958	.002	<.001	3	4
BONE	ADAMTS12 →	-4.127	-1.822	<.001	<.001	3	4
SOFT_TISSUE	EPC1 →	+0.418	+1.199	.002	.007	3	4
URINARY_TRACT	MAPK8 →	-1.532	-1.997	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CORO2A by Retina vasculature morphogenesis in camera-type eye activity — URINARY_TRACT

Explore this box plot interactively →