Establishment or maintenance of bipolar cell polarity

Across TCGA patient cohorts, RNA activity of the Establishment or maintenance of bipolar cell polarity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DEF6, LCP2, and PTPRC, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of bipolar cell polarity activity versus DEF6 in GBM (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DEF6 →	-0.568	-0.047	<.001	.001	3	9
GBM	LCP2 →	-0.551	-0.050	<.001	<.001	3	9
HNSC	PTPRC →	-0.616	-0.056	<.001	<.001	3	9
HNSC	GIMAP8 →	-0.481	-0.053	<.001	<.001	3	9
HNSC	STK10 →	-0.354	-0.044	<.001	<.001	3	8
GBM	WAS →	-0.546	-0.041	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061245 vs DEF6 — GBM

Explore this scatter interactively →