Establishment or maintenance of bipolar cell polarity

Across TCGA patient cohorts, RNA activity of the Establishment or maintenance of bipolar cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf210, FKBP11, and MAP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of bipolar cell polarity activity versus C1orf210 in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C1orf210 →	+0.822	+0.629	.003	.002	3	5
HNSC	FKBP11 →	-0.418	-0.718	.002	.006	3	5
HNSC	MAP7 →	+0.974	+1.016	<.001	.001	3	4
UCEC	PCBD1 →	+0.642	+1.519	<.001	<.001	3	4
UCEC	FAM110C →	+1.220	+0.930	<.001	<.001	3	4
HNSC	BSPRY →	+1.350	+1.072	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061245 vs C1orf210 — CCRCC

Explore this scatter interactively →