Establishment or maintenance of bipolar cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of bipolar cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHA1, PROM2, and SH3BP1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of bipolar cell polarity activity versus EPHA1 in PANCREAS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EPHA1 →	+1.936	+0.088	<.001	<.001	3	13
OESOPHAGUS	PROM2 →	+3.811	+0.169	.001	.001	3	11
PANCREAS	SH3BP1 →	+1.730	+0.124	<.001	<.001	3	11
OVARY	SCRIB →	+0.924	+0.079	<.001	<.001	3	10
OESOPHAGUS	EPHB3 →	+2.239	+0.134	<.001	.002	3	10
SKIN	PKP3 →	+2.509	+0.118	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061245 vs EPHA1 — PANCREAS

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