Establishment or maintenance of bipolar cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of bipolar cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIX1L, EPHA1, and STARD9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of bipolar cell polarity activity versus LIX1L in URINARY_TRACT (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LIX1L →	+2.506	+0.402	.002	.001	3	9
URINARY_TRACT	EPHA1 →	-4.294	-0.465	<.001	.001	3	8
URINARY_TRACT	STARD9 →	+1.912	+0.473	.001	<.001	3	8
URINARY_TRACT	ERBB3 →	-3.419	-0.449	<.001	.001	3	8
URINARY_TRACT	LLGL2 →	-3.054	-0.605	<.001	<.001	3	8
URINARY_TRACT	PLEKHG6 →	-4.447	-0.632	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061245 vs LIX1L — URINARY_TRACT

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