Mammary gland epithelium development

Across TCGA patient cohorts, RNA activity of the Mammary gland epithelium development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF703_S252, ADD3, and CDC23_S588, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland epithelium development activity versus ZNF703_S252 in PDAC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZNF703_S252 →	+0.656	+0.020	<.001	.003	3	5
BRCA	ADD3 →	+0.506	+0.039	<.001	<.001	3	5
OV	CDC23_S588 →	-0.606	-0.031	<.001	.006	3	4
UCEC	RPL3L →	-0.679	-0.078	.002	.001	3	4
BRCA	MICALL1 →	-0.297	-0.028	.001	<.001	3	4
BRCA	WNT5A →	+0.849	+0.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061180 vs ZNF703_S252 — PDAC

Explore this scatter interactively →