Mammary gland epithelium development

Across TCGA patient cohorts, RNA activity of the Mammary gland epithelium development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FEZ2_S195, ARHGAP23_S372, and TNS1_S1314, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland epithelium development activity versus FEZ2_S195 in GBM (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FEZ2_S195 →	-0.553	-1.187	<.001	<.001	3	3
BRCA	ARHGAP23_S372 →	-0.503	-0.769	<.001	.001	3	3
CCRCC	TNS1_S1314 →	-0.604	-0.601	<.001	.001	3	3
BRCA	CENATAC →	+0.299	+0.788	<.001	.001	3	3
GBM	ASMTL_S228 →	+0.658	+0.749	<.001	<.001	3	2
GBM	SCRIB_S1475 →	+0.339	+0.765	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061180 vs FEZ2_S195 — GBM

Explore this scatter interactively →