Mammary gland epithelium development

Across TCGA cell cohorts, RNA activity of the Mammary gland epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1BP1, HDAC6, and GBE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGB1BP1 grouped by Mammary gland epithelium development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ITGB1BP1 →	-1.028	-1.312	<.001	<.001	3	4
LUNG_SCLC	HDAC6 →	+1.153	+0.856	.001	.006	3	4
CNS	GBE1 →	-1.316	-0.846	.003	.009	3	3
CNS	FITM1 →	+0.370	+0.988	.002	<.001	3	3
CNS	TCF7L1 →	+1.279	+1.149	.001	<.001	3	3
CNS	NMNAT2 →	-2.156	-1.052	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGB1BP1 by Mammary gland epithelium development activity — CNS

Explore this box plot interactively →