Mammary gland epithelium development

Across TCGA cell cohorts, RNA activity of the Mammary gland epithelium development pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR86, SENP2, and ZCCHC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR86 grouped by Mammary gland epithelium development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WDR86 →	-0.147	-0.115	.003	.005	3	5
LUNG_NSCLC_LUSC	SENP2 →	-0.230	-0.234	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ZCCHC3 →	-0.235	-0.134	<.001	<.001	3	4
KIDNEY	BCL11B →	-0.148	-0.116	.003	.005	3	4
STOMACH	LGSN →	-0.203	-0.176	.002	.007	3	4
BONE	NANOG →	+0.245	+0.250	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR86 by Mammary gland epithelium development activity — SKIN

Explore this box plot interactively →