Mammary gland epithelium development

Across TCGA cell cohorts, RNA activity of the Mammary gland epithelium development pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIB2, SLCO3A1, and NOMO1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIB2 grouped by Mammary gland epithelium development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CIB2 →	-0.256	-1.523	.005	.002	3	3
OESOPHAGUS	SLCO3A1 →	+0.182	+1.819	.002	<.001	3	3
SKIN	NOMO1 →	+0.217	+1.596	<.001	<.001	3	2
SKIN	RABAC1 →	+0.416	+1.684	.001	<.001	3	2
SKIN	STEAP1B →	-0.176	-1.447	.005	<.001	3	2
SKIN	ARID1A →	+0.596	+1.730	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIB2 by Mammary gland epithelium development activity — OESOPHAGUS

Explore this box plot interactively →