Mammary gland epithelium development

Across TCGA cell cohorts, RNA activity of the Mammary gland epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBD1, SDHC, and PMEPA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland epithelium development activity versus TUBD1 in OESOPHAGUS (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TUBD1 →	-0.750	-1.200	.009	.001	3	3
OESOPHAGUS	SDHC →	-0.587	-1.193	.003	<.001	3	3
LARGE_INTESTINE	PMEPA1 →	+4.180	+1.210	<.001	<.001	3	3
BLOOD_Lymphoma	TEP1 →	-0.949	-1.479	<.001	.002	3	3
BLOOD_Lymphoma	ZNF236 →	-0.822	-1.479	.003	.002	3	3
LARGE_INTESTINE	RPS27 →	-0.561	-0.962	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061180 vs TUBD1 — OESOPHAGUS

Explore this scatter interactively →