Negative regulation of insulin secretion involved in cellular response to glucose stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of insulin secretion involved in cellular response to glucose stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRRC8A, CYRIB, and AKNA_S1228, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of insulin secretion involved in cellular response to glucose stimulus activity versus LRRC8A in HNSC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRRC8A →	-0.298	-0.053	.005	.006	3	5
CCRCC	CYRIB →	+0.238	+0.040	<.001	.005	3	4
CCRCC	AKNA_S1228 →	+0.347	+0.050	.001	<.001	3	4
HNSC	FRMD6_S544 →	-0.579	-0.058	<.001	<.001	3	4
HNSC	CELSR2 →	-0.483	-0.062	<.001	<.001	3	4
LSCC	FAM110C_S202 →	-1.065	-0.059	.005	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061179 vs LRRC8A — HNSC

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