Negative regulation of insulin secretion involved in cellular response to glucose stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of insulin secretion involved in cellular response to glucose stimulus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SKP179, DACT3, and CDO1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of insulin secretion involved in cellular response to glucose stimulus activity versus RN7SKP179 in GBM (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RN7SKP179 →	-0.407	-0.103	.006	.006	3	3
CCRCC	DACT3 →	-0.533	-0.230	.004	<.001	3	3
COAD	CDO1 →	-0.773	-0.131	<.001	.002	3	3
COAD	ADH1B →	-0.785	-0.096	.007	.005	3	3
COAD	VGLL3 →	-0.588	-0.134	.008	.001	3	3
OV	B3GALNT1 →	-0.718	-0.308	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061179 vs RN7SKP179 — GBM

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