3'-UTR-mediated mRNA destabilization

Across TCGA patient cohorts, RNA activity of the 3'-UTR-mediated mRNA destabilization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC2, ZDHHC5_S380, and SPAG9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-UTR-mediated mRNA destabilization activity versus TACC2 in LUAD (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TACC2 →	-0.389	-0.034	<.001	.002	3	5
PDAC	ZDHHC5_S380 →	-0.532	-0.025	<.001	.007	3	5
HNSC	SPAG9 →	-0.273	-0.082	<.001	<.001	3	4
PDAC	CTNND1_Y291 →	-0.630	-0.029	<.001	.001	3	4
BRCA	JUNB →	+0.327	+0.031	<.001	.003	3	4
CCRCC	PPP1R18_S224 →	+0.341	+0.054	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061158 vs TACC2 — LUAD

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