3'-UTR-mediated mRNA destabilization

Across TCGA patient cohorts, RNA activity of the 3'-UTR-mediated mRNA destabilization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIF, RPL12P21, and LRRC37A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-UTR-mediated mRNA destabilization activity versus LIF in UCEC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIF →	+1.545	+0.164	.001	<.001	3	3
COAD	RPL12P21 →	-0.073	-0.215	.005	.003	3	3
PDAC	LRRC37A →	-0.343	-0.154	<.001	<.001	3	3
PDAC	RHD →	-0.447	-0.140	.004	.001	3	3
UCEC	CLN3 →	-0.352	-0.118	.007	.001	3	3
LSCC	IFI27 →	-1.502	-0.163	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061158 vs LIF — UCEC

Explore this scatter interactively →