3'-UTR-mediated mRNA destabilization

Across TCGA cell cohorts, RNA activity of the 3'-UTR-mediated mRNA destabilization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHNYN, ZFP36L2, and ZFP36, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-UTR-mediated mRNA destabilization activity versus KHNYN in STOMACH (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KHNYN →	+0.845	+0.130	.001	.002	2	16
STOMACH	ZFP36L2 →	+1.623	+0.144	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	ZFP36 →	+2.008	+0.167	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	TIMM23 →	-0.809	-0.144	.003	<.001	3	14
PANCREAS	ITPKC →	+1.084	+0.110	<.001	<.001	3	12
KIDNEY	HOOK2 →	+1.141	+0.090	.001	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061158 vs KHNYN — STOMACH

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