Pulmonary artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Pulmonary artery morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC5, ACLY, and BRI3BP_S248, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary artery morphogenesis activity versus RFC5 in HNSC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RFC5 →	-0.264	-0.061	<.001	.003	3	4
UCEC	ACLY →	-0.359	-0.106	<.001	.001	3	4
LSCC	BRI3BP_S248 →	-1.189	-0.079	.002	<.001	3	4
HNSC	MCM2 →	-0.357	-0.059	<.001	.004	3	4
COAD	BZW2 →	-0.251	-0.051	.001	.001	3	4
BRCA	CCS →	+0.236	+0.059	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061156 vs RFC5 — HNSC

Explore this scatter interactively →