Pulmonary artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Pulmonary artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP2, HPN, and RASA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary artery morphogenesis activity versus LRP2 in BRCA (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRP2 →	+1.788	+0.545	<.001	<.001	3	4
BRCA	HPN →	+1.478	+0.427	<.001	.005	3	4
BRCA	RASA3 →	-0.735	-0.609	<.001	.002	3	4
UCEC	ST8SIA6 →	+0.856	+0.549	.001	.003	3	3
LSCC	ABCA3 →	+1.052	+0.439	<.001	<.001	3	3
LSCC	RPS10P14 →	+0.447	+0.421	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061156 vs LRP2 — BRCA

Explore this scatter interactively →