Pulmonary artery morphogenesis

Across TCGA cell cohorts, RNA activity of the Pulmonary artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF20, ITGB4, and AGAP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF20 grouped by Pulmonary artery morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF20 →	-1.012	-1.190	.001	<.001	3	3
LUNG_SCLC	ITGB4 →	-1.671	-1.025	.005	.002	3	3
LUNG_SCLC	AGAP3 →	+0.766	+1.455	<.001	<.001	3	3
STOMACH	FUCA2 →	-1.398	-1.248	.008	.005	3	3
STOMACH	AP3D1 →	+0.653	+0.888	.002	.007	3	3
STOMACH	TCF3 →	+1.078	+0.908	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF20 by Pulmonary artery morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →