Pulmonary artery morphogenesis

Across TCGA cell cohorts, RNA activity of the Pulmonary artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAG1, STRA6, and CCDC33, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pulmonary artery morphogenesis activity versus JAG1 in LIVER (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	JAG1 →	+3.112	+1.304	<.001	.002	3	18
SOFT_TISSUE	STRA6 →	+3.480	+1.506	<.001	<.001	3	9
LUNG_SCLC	CCDC33 →	+1.906	+0.907	<.001	<.001	3	8
URINARY_TRACT	SULF2 →	+3.577	+1.160	<.001	.002	3	7
PANCREAS	STMN1 →	-0.920	-0.879	.001	<.001	3	7
OVARY	MMP7 →	+4.339	+1.205	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061156 vs JAG1 — LIVER

Explore this scatter interactively →