Regulation of proteasomal protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of proteasomal protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, MAP1B, and TIMP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of proteasomal protein catabolic process activity versus RPL5 in CCRCC (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL5 →	-0.252	-0.036	<.001	<.001	3	7
COAD	MAP1B →	+0.565	+0.026	<.001	.001	3	7
CCRCC	TIMP2 →	+0.537	+0.035	<.001	<.001	3	6
OV	MAP1A →	+0.346	+0.033	.002	.003	2	7
OV	PRKG1 →	+0.510	+0.026	.001	.001	3	6
LSCC	RPL4 →	-0.290	-0.028	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061136 vs RPL5 — CCRCC

Explore this scatter interactively →