Regulation of proteasomal protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of proteasomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM53A, SNX25P1, and PTDSS1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of proteasomal protein catabolic process activity versus FAM53A in COAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAM53A →	+0.302	+0.118	.005	.004	3	2
COAD	SNX25P1 →	+0.390	+0.111	.006	<.001	3	2
OV	PTDSS1 →	+0.922	+0.150	.007	<.001	3	2
COAD	EARS2 →	+0.263	+0.129	.007	.001	3	1
COAD	DHDH →	+0.435	+0.116	.009	<.001	3	1
COAD	IL17F →	+0.387	+0.112	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061136 vs FAM53A — COAD

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