Regulation of proteasomal protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of proteasomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OLA1, SRSF7, and GTF2F1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of proteasomal protein catabolic process activity versus OLA1 in BREAST (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OLA1 →	+1.052	+0.233	<.001	.003	2	6
LIVER	SRSF7 →	+0.595	+0.250	.003	.005	3	5
BONE	GTF2F1 →	+0.868	+0.242	.001	.007	3	5
UPPER_AERODIGESTIVE_TRACT	RTN4IP1 →	+1.051	+0.397	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	RPE →	+1.452	+0.424	<.001	.003	3	5
PANCREAS	CCT4 →	+1.002	+0.352	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061136 vs OLA1 — BREAST

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