Negative regulation of protein tyrosine kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein tyrosine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNFAIP8L2, DOCK11, and FLI1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein tyrosine kinase activity activity versus TNFAIP8L2 in GBM (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFAIP8L2 →	+0.504	+0.048	<.001	<.001	3	7
GBM	DOCK11 →	+0.313	+0.062	<.001	<.001	3	7
GBM	FLI1 →	+0.517	+0.055	<.001	.007	3	7
GBM	APBB1IP →	+0.478	+0.059	<.001	<.001	3	7
LSCC	ARHGAP25 →	+0.535	+0.070	<.001	<.001	3	7
COAD	PLEKHO2 →	+0.373	+0.027	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061099 vs TNFAIP8L2 — GBM

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