Negative regulation of protein tyrosine kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein tyrosine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5A, TMEM265, and LY6G6C, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein tyrosine kinase activity activity versus GPRC5A in LUNG_NSCLC_LUSC (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GPRC5A →	+4.824	+1.657	.001	.002	3	10
LUNG_NSCLC_LUAD	TMEM265 →	+1.850	+0.953	.002	.001	3	7
LUNG_NSCLC_LUAD	LY6G6C →	+0.598	+0.590	.001	.003	3	5
STOMACH	GJB3 →	+3.367	+1.119	.002	.005	3	5
BREAST	CBX2 →	-1.253	-0.921	<.001	.001	3	5
LUNG_NSCLC_LUSC	ANKRD13B →	-1.261	-1.665	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061099 vs GPRC5A — LUNG_NSCLC_LUSC

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