Positive regulation of protein tyrosine kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein tyrosine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR34, CXCL2, and COL4A5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR34 grouped by Positive regulation of protein tyrosine kinase activity-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GPR34 →	-0.050	-2.012	<.001	<.001	3	4
KIDNEY	CXCL2 →	-2.500	-1.051	<.001	<.001	3	4
STOMACH	COL4A5 →	+2.686	+1.507	<.001	<.001	3	4
BLOOD_Myeloma	CAMSAP2 →	-0.948	-1.624	.008	.003	3	3
BLOOD_Myeloma	MAGI1 →	-1.717	-1.422	.002	.001	3	3
BLOOD_Myeloma	PDLIM3 →	-3.782	-1.452	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR34 by Positive regulation of protein tyrosine kinase activity activity — BLOOD_Myeloma

Explore this box plot interactively →