Positive regulation of protein tyrosine kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein tyrosine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF3, TTC23L, and MGAT4A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein tyrosine kinase activity activity versus IRF3 in BREAST (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IRF3 →	+0.838	+1.490	<.001	<.001	3	2
BREAST	TTC23L →	+1.196	+1.383	.001	.001	3	2
BREAST	MGAT4A →	+2.789	+1.723	.005	.001	2	3
BLOOD_Leukemia	TMEM35B →	+0.984	+1.827	.004	.003	2	2
BLOOD_Leukemia	ZNF285 →	-2.199	-1.676	.004	.002	2	2
BLOOD_Leukemia	PRKCH →	+3.034	+1.827	.009	.003	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061098 vs IRF3 — BREAST

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