Regulation of protein tyrosine kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of protein tyrosine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILK, ACTR3, and CLP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein tyrosine kinase activity activity versus ILK in BRCA (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ILK →	+0.363	+0.027	<.001	<.001	3	8
GBM	ACTR3 →	+0.224	+0.041	<.001	.002	3	7
GBM	CLP1 →	-0.256	-0.050	<.001	<.001	3	7
BRCA	TLN1 →	+0.320	+0.034	<.001	<.001	3	7
LSCC	RENBP →	+0.431	+0.034	<.001	<.001	3	7
GBM	ARPC1B →	+0.580	+0.049	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061097 vs ILK — BRCA

Explore this scatter interactively →