Regulation of protein tyrosine kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of protein tyrosine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF3R, SQOR, and COX20, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein tyrosine kinase activity activity versus CSF3R in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSF3R →	+1.193	+0.245	<.001	.001	3	5
HNSC	SQOR →	+1.078	+0.265	<.001	<.001	3	5
HNSC	COX20 →	-0.437	-0.166	.002	<.001	3	5
COAD	TMEM246-AS1 →	-0.098	-0.209	.008	.003	3	4
GBM	DEPDC5 →	-0.331	-0.360	<.001	.003	3	4
GBM	GPR89A →	-0.171	-0.266	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061097 vs CSF3R — UCEC

Explore this scatter interactively →