Regulation of protein tyrosine kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of protein tyrosine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5A, UPK2, and ELF3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein tyrosine kinase activity activity versus GPRC5A in OESOPHAGUS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPRC5A →	+3.174	+1.138	.001	.005	3	9
LARGE_INTESTINE	UPK2 →	+1.673	+0.886	.007	.004	2	7
OVARY	ELF3 →	+3.171	+1.034	.001	.004	3	6
LUNG_NSCLC_LUAD	ADGRF1 →	+2.672	+0.864	<.001	<.001	3	6
URINARY_TRACT	DIXDC1 →	-1.876	-1.426	.002	.004	3	6
BLOOD_Lymphoma	VAMP8 →	+2.152	+0.493	.004	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061097 vs GPRC5A — OESOPHAGUS

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