Positive regulation of phospholipid translocation

Across TCGA patient cohorts, RNA activity of the Positive regulation of phospholipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAB1, ABI3, and GMFG, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phospholipid translocation activity versus STAB1 in ACC (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	STAB1 →	-1.639	-0.114	<.001	<.001	3	24
HNSC	ABI3 →	-1.263	-0.144	<.001	<.001	3	24
HNSC	GMFG →	-0.943	-0.125	<.001	<.001	3	24
BLCA	FCER1G →	-1.459	-0.096	<.001	<.001	3	24
CHOL	CAVIN3 →	-1.870	-0.135	<.001	.001	3	24
UVM	FAM167B →	-1.111	-0.054	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061092 vs STAB1 — ACC

Explore this scatter interactively →