Positive regulation of phospholipid translocation

Across TCGA patient cohorts, RNA activity of the Positive regulation of phospholipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8A1, CEACAM3, and PPP4R4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phospholipid translocation activity versus ATP8A1 in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP8A1 →	+1.244	+0.614	<.001	<.001	3	5
LSCC	CEACAM3 →	+0.874	+0.248	<.001	<.001	3	5
GBM	PPP4R4 →	+0.745	+0.679	.002	<.001	3	4
LSCC	SELL →	+0.966	+0.266	<.001	<.001	3	4
GBM	TMEM125 →	+1.318	+0.656	<.001	<.001	3	4
GBM	CYP4X1 →	+0.857	+0.761	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061092 vs ATP8A1 — GBM

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