Positive regulation of phospholipid translocation

Across TCGA cell cohorts, RNA activity of the Positive regulation of phospholipid translocation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FASLG, ABCB4, and ATP8A1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FASLG grouped by Positive regulation of phospholipid translocation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FASLG →	-0.212	-0.681	.001	.002	3	11
BLOOD_Leukemia	ABCB4 →	-0.331	-1.204	<.001	.006	3	10
BONE	ATP8A1 →	-0.312	-1.430	.001	.001	2	6
LARGE_INTESTINE	TMEM30A →	-0.160	-0.961	.004	.006	2	5
OVARY	ATP8A2 →	-0.208	-0.877	<.001	.001	2	4
OVARY	TLE3 →	+0.149	+0.812	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FASLG by Positive regulation of phospholipid translocation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →