Positive regulation of phospholipid translocation

Across TCGA cell cohorts, RNA activity of the Positive regulation of phospholipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRCC4, IRF2BP1, and TLNRD1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phospholipid translocation activity versus XRCC4 in URINARY_TRACT (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	XRCC4 →	+1.304	+0.237	<.001	<.001	3	20
BREAST	IRF2BP1 →	-1.099	-0.214	<.001	<.001	3	13
SKIN	TLNRD1 →	-0.967	-0.135	.002	.002	3	12
BLOOD_Leukemia	ATP8A2 →	-0.905	-0.144	<.001	<.001	3	11
BONE	PIAS4 →	-0.976	-0.276	<.001	<.001	3	10
OESOPHAGUS	NUDCD3 →	-0.851	-0.145	.005	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061092 vs XRCC4 — URINARY_TRACT

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