Regulation of phospholipid translocation

Across TCGA patient cohorts, RNA activity of the Regulation of phospholipid translocation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKCD, SERPINH1, and TPD52, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid translocation activity versus PRKCD in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRKCD →	+0.491	+0.111	<.001	<.001	3	8
GBM	SERPINH1 →	-0.520	-0.065	<.001	.004	3	6
GBM	TPD52 →	+0.578	+0.114	<.001	<.001	3	6
PDAC	CKAP4 →	-0.484	-0.100	<.001	<.001	3	6
OV	COL11A1 →	-0.952	-0.083	.001	<.001	3	6
LSCC	COL5A2 →	-0.628	-0.082	.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061091 vs PRKCD — OV

Explore this scatter interactively →