Regulation of phospholipid translocation

Across TCGA patient cohorts, RNA activity of the Regulation of phospholipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENPP2, RASGRF1, and PRPH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid translocation activity versus ENPP2 in GBM (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ENPP2 →	+1.641	+0.609	<.001	.001	3	4
GBM	RASGRF1 →	+1.008	+0.523	<.001	<.001	3	4
CCRCC	PRPH2 →	+0.318	+0.481	.001	.003	3	3
CCRCC	TMEM121B →	+0.192	+0.490	.001	.002	3	3
CCRCC	MIR326 →	+0.902	+0.695	<.001	<.001	3	3
CCRCC	RASA4CP →	+0.288	+0.661	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061091 vs ENPP2 — GBM

Explore this scatter interactively →