Regulation of phospholipid translocation

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K9, CCDC17, and GNAZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K9 grouped by Regulation of phospholipid translocation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MAP3K9 →	+0.808	+1.249	.001	<.001	2	6
LUNG_NSCLC_LUSC	CCDC17 →	+0.446	+1.544	.003	<.001	3	4
CNS	GNAZ →	+0.930	+1.041	.004	<.001	3	3
CNS	KIAA1841 →	+0.477	+0.831	.006	.003	3	3
BREAST	PARD6G →	+0.986	+0.712	<.001	.002	3	3
BREAST	ASCL2 →	+1.693	+0.884	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K9 by Regulation of phospholipid translocation activity — KIDNEY

Explore this box plot interactively →