Positive regulation of myeloid leukocyte cytokine production involved in immune response

pathway activity — cross-omics
GO:0061081Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid leukocyte cytokine production involved in immune response pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NECAP2, ARHGEF6, and STAB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte cytokine production involved in immune response activity versus NECAP2 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCNECAP2 →+0.351+0.073<.001<.001310
LSCCARHGEF6 →+0.528+0.087<.001<.001310
GBMSTAB1 →+0.647+0.098<.001<.00139
OVC17orf75 →-0.460-0.038.001.00139
OVGNB4 →+0.514+0.040<.001<.00139
GBMLIG3 →-0.464-0.098<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061081 vs NECAP2 — HNSC

Per-sample scatter of Positive regulation of myeloid leukocyte cytokine production involved in immune response activity vs NECAP2 in HNSC.

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Exploration