Positive regulation of myeloid leukocyte cytokine production involved in immune response

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid leukocyte cytokine production involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMSN1, SIGLEC10, and HECTD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte cytokine production involved in immune response activity versus SAMSN1 in LSCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMSN1 →	+1.070	+0.238	<.001	<.001	3	6
HNSC	SIGLEC10 →	+0.605	+0.127	.003	.001	3	6
UCEC	HECTD1 →	-0.537	-0.268	<.001	<.001	3	6
LSCC	HSD17B8 →	-0.737	-0.238	<.001	<.001	3	6
LSCC	CD7 →	+0.770	+0.247	<.001	<.001	3	6
LSCC	IL2RA →	+0.757	+0.188	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061081 vs SAMSN1 — LSCC

Explore this scatter interactively →