Positive regulation of myeloid leukocyte cytokine production involved in immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid leukocyte cytokine production involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALM3, PDCD1LG2, and ALDH4A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte cytokine production involved in immune response activity versus CALM3 in OVARY (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CALM3 →	-0.969	-0.091	.001	.001	3	8
SOFT_TISSUE	PDCD1LG2 →	+1.849	+0.097	<.001	.001	3	8
OVARY	ALDH4A1 →	-1.075	-0.098	.001	<.001	3	7
BREAST	MISP3 →	-1.560	-0.094	<.001	<.001	3	7
SKIN	SGSM3 →	-0.722	-0.092	<.001	<.001	3	7
SKIN	SLC22A23 →	-1.199	-0.111	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061081 vs CALM3 — OVARY

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