Ciliary body morphogenesis

pathway activity — cross-omics
GO:0061073Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ciliary body morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHLDB1_S419, RPLP2, and COL1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAPHLDB1_S419 →+0.941+0.102<.001<.00136
BRCARPLP2 →-0.181-0.072<.001<.00135
GBMCOL1A1 →+0.924+0.079<.001<.00135
GBMCOL1A2 →+0.873+0.078<.001<.00135
OVCTHRC1 →+0.990+0.089.001.00535
CCRCCMDK →+1.124+0.095.004.00126
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration