Ciliary body morphogenesis

pathway activity — cross-omics
GO:0061073Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ciliary body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAG1, ADM, and FABP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCJAG1 →+1.083+0.581<.001<.00134
LSCCADM →+1.009+0.659.002<.00134
LSCCFABP5 →+1.149+0.597<.001<.00134
GBMDNAH10 →-0.395-0.470.006.00334
LSCCMIR6870 →+0.707+0.452.001<.00134
OVCCDC9 →+0.573+0.348<.001.00934
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration