Iris morphogenesis

Across TCGA patient cohorts, RNA activity of the Iris morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHF11_S17, ASAP2_S701, and IGSF8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iris morphogenesis activity versus PHF11_S17 in PDAC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PHF11_S17 →	-0.688	-0.059	<.001	.001	3	4
CCRCC	ASAP2_S701 →	+0.225	+0.064	.003	.003	3	4
OV	IGSF8 →	+0.340	+0.079	.001	<.001	3	4
OV	MEST →	+0.586	+0.057	.003	.004	3	4
CCRCC	KIF21A →	-0.337	-0.068	<.001	<.001	3	4
CCRCC	MPP6 →	-0.265	-0.052	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061072 vs PHF11_S17 — PDAC

Explore this scatter interactively →