Iris morphogenesis

Across TCGA patient cohorts, RNA activity of the Iris morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTM5, ABCA6, and CDO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iris morphogenesis activity versus GSTM5 in HNSC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GSTM5 →	+0.289	+0.138	.009	.009	3	4
LUAD	ABCA6 →	+0.440	+0.224	.009	.003	3	4
HNSC	CDO1 →	+1.306	+0.213	<.001	.003	3	3
LUAD	S1PR1 →	+0.531	+0.251	.001	.001	3	3
COAD	TMEM241 →	-0.537	-0.262	.004	.002	3	3
LUAD	CXCL12 →	+0.639	+0.253	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061072 vs GSTM5 — HNSC

Explore this scatter interactively →