Iris morphogenesis

Across TCGA cell cohorts, RNA activity of the Iris morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO5A, OR52I1, and RNF133, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYO5A grouped by Iris morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MYO5A →	+0.176	+0.204	.003	.009	3	3
BLOOD_Leukemia	OR52I1 →	+0.245	+0.174	.006	.001	3	3
PANCREAS	RNF133 →	+0.183	+1.327	.004	<.001	3	3
OESOPHAGUS	RTF1 →	-0.226	-0.946	<.001	.005	3	3
LUNG_NSCLC_LUAD	LINC00518 →	-0.096	-0.706	.003	.001	3	3
CNS	DOK2 →	+0.395	+0.185	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYO5A by Iris morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →