Somite development

Across TCGA patient cohorts, RNA activity of the Somite development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETD1B_S211, FGD2_S11, and BUD13_S271, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somite development activity versus SETD1B_S211 in GBM (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SETD1B_S211 →	+0.595	+0.695	<.001	.002	3	3
GBM	FGD2_S11 →	-2.318	-1.303	<.001	<.001	3	3
OV	BUD13_S271 →	+0.578	+0.800	.001	.001	3	3
UCEC	DVL3_T133 →	+1.499	+0.628	<.001	.002	3	3
PDAC	WDR7_S1154 →	-0.540	-1.059	<.001	<.001	3	3
BRCA	STX4_S117 →	-0.414	-0.605	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061053 vs SETD1B_S211 — GBM

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