Somite development

Across TCGA cell cohorts, RNA activity of the Somite development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCAT, PRXL2B, and PES1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somite development activity versus MCAT in STOMACH (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MCAT →	+0.919	+1.178	.001	.001	3	5
STOMACH	PRXL2B →	+1.821	+1.294	.006	.003	2	6
OVARY	PES1 →	+1.004	+1.369	<.001	<.001	3	5
OVARY	MRPL4 →	+0.743	+1.327	<.001	<.001	3	5
PANCREAS	EPS8L2 →	-2.066	-1.324	<.001	<.001	3	5
STOMACH	RPS2 →	+1.038	+1.075	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061053 vs MCAT — STOMACH

Explore this scatter interactively →