Negative regulation of cell growth involved in cardiac muscle cell development

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell growth involved in cardiac muscle cell development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLXNC1, C1QA, and C1R, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell growth involved in cardiac muscle cell development activity versus PLXNC1 in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLXNC1 →	+0.310	+0.060	.001	<.001	3	6
CCRCC	C1QA →	+0.600	+0.052	<.001	<.001	3	5
CCRCC	C1R →	+0.575	+0.056	<.001	<.001	3	5
OV	C1S →	+0.574	+0.047	<.001	.003	3	5
LSCC	ITGA5 →	+0.330	+0.049	.002	.006	3	5
CCRCC	RCN3 →	+0.571	+0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061052 vs PLXNC1 — LSCC

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