Negative regulation of cell growth involved in cardiac muscle cell development

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell growth involved in cardiac muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMRN2, GPN2, and ADPRS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MMRN2 grouped by Negative regulation of cell growth involved in cardiac muscle cell development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MMRN2 →	-1.000	-0.568	.003	.004	3	4
SOFT_TISSUE	GPN2 →	-0.755	-0.782	.002	.004	3	4
SOFT_TISSUE	ADPRS →	-0.991	-0.520	<.001	<.001	3	3
LARGE_INTESTINE	NABP1 →	-1.340	-0.291	.008	.006	3	3
LARGE_INTESTINE	CHID1 →	-0.630	-0.290	<.001	<.001	3	3
STOMACH	PSMD13 →	+1.316	+0.405	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MMRN2 by Negative regulation of cell growth involved in cardiac muscle cell development activity — OVARY

Explore this box plot interactively →