Positive regulation of cell growth involved in cardiac muscle cell development

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell growth involved in cardiac muscle cell development pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDN1, IGF1, and AKAP6, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDN1 grouped by Positive regulation of cell growth involved in cardiac muscle cell development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EDN1 →	-0.554	-1.808	.009	.001	2	14
LIVER	IGF1 →	-0.396	-2.199	<.001	<.001	3	10
BLOOD_Myeloma	AKAP6 →	-0.510	-2.106	.006	<.001	3	9
SKIN	PARP2 →	-0.133	-1.120	.005	.005	3	6
LARGE_INTESTINE	ERCC6L →	-0.261	-1.285	.002	<.001	3	5
LIVER	PNPT1 →	-0.509	-1.746	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDN1 by Positive regulation of cell growth involved in cardiac muscle cell development activity — LIVER

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